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When a commuter ship capsizes, the ED finds itself under water as the staff struggles to treat the influx of new patients and deal with bold new employees taking charge.

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Lenox continues to rankle Archer as the two tackle their new roles. Ripley faces possible suspension over what really happened to Pawel. Goodwin is forced to make layoffs.

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Asher treats a woman whose undiagnosed condition threatens the lives of both her and her unborn child. Goodwin receives a chilling message while battling the hospital higher-ups.

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A familiar face returns to the ED. Ripley and Charles treat a woman with a rare disorder. Frost suspects that his patient's father is lying about his daughter's condition.

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Halloween chaos takes over the ED. Asher helps a pregnant woman with an autistic son. Charles clashes with Nurse Jackie on a psych case.

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Chicago P.D. steps up Goodwin's security after she's threatened online by a former employee. Archer and Frost treat victims from a disciplinary camp injured during a rockslide. Maggie gets roped into delivering a high schooler's baby.

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Ripley and Frost uncover shocking information that conflicts with their patient's DNR. Asher facilitates an unexpected reunion. The tension between Archer and Lenox comes to a head.

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Goodwin's troubles persist. Charles clashes with his former resident over a depressed patient. Lenox and Ripley treat a car accident victim who recently reunited with his college sweetheart.

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The team fights to save the life of one of their own. Frost and Abrams butt heads with their patient. Asher helps a religious young woman with an ectopic pregnancy.

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An army of surgeons prepares to separate conjoined twins. Asher reconnects with someone from her past. Archer treats a tyrannical boss with a heart problem.

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Following the subway tunnel collapse, Ruzek and Kidd treat injured passengers and track down the missing offender. Archer and Frost perform a life-saving amputation. The crossover starts on Chicago Fire S13E11 In the Trenches (I). It continues on Chicago P.D. S12E11 In the Trenches (III).

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Goodwin struggles with the psychological aftermath of her attack. Ripley treats a patient with helicopter parents. An ED staffer makes a mistake that may cost them their job.

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Lenox's mentorship is put to the test. Asher helps a religious young woman with an ectopic pregnancy. Ripley's self-destructive behavior continues to escalate.

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Gaffney gets a surprise visit from a National Accreditation Board of Hospitals representative. Hannah and Naomi search for the cause of a young girl's infection. Lenox and Frost work together to save the victim of an accidental shooting.

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Ripley struggles to rescue a woman and her daughter trapped in an abandoned well. An old friend from Frost's TV days shadows Maggie. Asher discovers an extremely rare condition in her patient's ultrasound.

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